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GLP-1RAs are a class of drugs that can activate the GLP-1 receptor and promote its binding to the specific receptor of pancreatic -cells, ultimately improving insulin concentration, inhibiting glucagon secretion, reducing food intake, and delaying gastric emptying (Drucker et al., 2017)
Onceweekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial
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2 Liraglutide is designed to bind to human albumin via a C16 fatty acid and a spacer covalently attached to Lys 26